Structure of PDB 2yy8 Chain A

Receptor sequence
>2yy8A (length=174) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
MIVVLRLGHRPEDKRVTTHVALTARAFGADGIIIASEEDEKVKESVEDVV
KRWGGPFFIEFNRNWRKVMKEFTGVKVHLTMYGLHVDDVIEELKEKLKKG
EDFMIIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVLLDRLLEGKGL
KKEFKGAKIKIVPQARGKKVVEVQ
3D structure
PDB2yy8 Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.206: tRNA (cytidine(56)-2'-O)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A L80 T81 M82 V108 G109 A110 E111 I127 H132 E134 A137 L79 T80 M81 V107 G108 A109 E110 I126 H131 E133 A136
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0106059 tRNA (cytidine(56)-2'-O)-methyltransferase activity
Biological Process
GO:0002128 tRNA nucleoside ribose methylation
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2yy8, PDBe:2yy8, PDBj:2yy8
PDBsum2yy8
PubMed18068186
UniProtO58214|TRM56_PYRHO tRNA (cytidine(56)-2'-O)-methyltransferase (Gene Name=PH0461)

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