Structure of PDB 2yxx Chain A

Receptor sequence
>2yxxA (length=385) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
DILRKVAEIHGTPTYVYFEETLRKRSRLVKEVFEGVNLLPTFAVKANNNP
VLLKILREEGFGMDVVTKGELLAAKLAGVPSHTVVWNGNGKSRDQMEHFL
REDVRIVNVDSFEEMEIWRELNPEGVEYFIRVNPEVDAKTHPHISTGLKK
HKFGIPLEDLDSFMERFRSMNIRGLHVHIGSQITRVEPFVEAFSKVVRAS
ERYGFEEINIGGGWGINYSGEELDLSSYREKVVPDLKRFKRVIVEIGRYI
VAPSGYLLLRVVLVKRRHNKAFVVVDGGMNVLIRPALYSAYHRIFVLGKQ
GKEMRADVVGPLCESGDVIAYDRELPEVEPGDIIAVENAGAYGYTMSNNY
NSTTRPAEVLVRENGRISLIRRRETEMDIFKDVVM
3D structure
PDB2yxx Crystal structure analysis of Diaminopimelate decarboxylate (lysA)
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K46 H179 E246
Catalytic site (residue number reindexed from 1) K45 H178 E245
Enzyme Commision number 4.1.1.20: diaminopimelate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K46 D65 H179 S182 G214 E246 G248 R249 Y343 K45 D64 H178 S181 G213 E245 G247 R248 Y342
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008836 diaminopimelate decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate

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Molecular Function
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Biological Process
External links
PDB RCSB:2yxx, PDBe:2yxx, PDBj:2yxx
PDBsum2yxx
PubMed
UniProtQ9X1K5|DCDA_THEMA Diaminopimelate decarboxylase (Gene Name=lysA)

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