Structure of PDB 2yxj Chain A

Receptor sequence
>2yxjA (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
SNRELVVDFLSYKLSQKGYSWSSEAVKQALREAGDEFELRYRRAFSDLTS
QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQ
VLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGN
3D structure
PDB2yxj Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N3C A F97 Y101 F105 V126 E129 L130 G138 R139 V141 Y195 F37 Y41 F45 V66 E69 L70 G78 R79 V81 Y135 MOAD: ic50=9nM
PDBbind-CN: -logKd/Ki=9.30,Ki=0.5nM
BindingDB: Ki=<1.000000nM,IC50=6nM,Kd=0.37nM,EC50=30nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:2yxj, PDBe:2yxj, PDBj:2yxj
PDBsum2yxj
PubMed17572662
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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