Structure of PDB 2yx1 Chain A

Receptor sequence
>2yx1A (length=323) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
PLCLKINKKHGEQTRRILIENNLLNKDYKITSEGNYLYLPIKDVDEDILK
SILNIEFELVDKELEEKPSFREIISKKYRKEIDEGLISLSYDVVGDLVIL
QISDEVDEKIRKEIGELAYKLIPCKGVFRRKRVRELEHLAGENRTLTIHK
ENGYRLWVDIAKVYFSPRLGGERARIMKKVSLNDVVVDMFAGVGPFSIAC
KNAKKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREVDVKGNRVI
MNLPKFAHKFIDKALDIVEEGGVIHYYTIGKDFDKAIKLFEKKCDCEVLE
KRIVKSYAPREYILALDFKINKK
3D structure
PDB2yx1 Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H227 E230 H214 E217
BS02 ZN A F303 C307 C309 F290 C294 C296
BS03 SFG A R186 F203 A204 P208 F209 D223 I224 D251 V252 N265 L266 R173 F190 A191 P195 F196 D210 I211 D238 V239 N252 L253
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yx1, PDBe:2yx1, PDBj:2yx1
PDBsum2yx1
PubMed18384044
UniProtQ58293|TRM5B_METJA tRNA (guanine(37)-N1)-methyltransferase Trm5b (Gene Name=trm5b)

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