Structure of PDB 2ytz Chain A

Receptor sequence
>2ytzA (length=371) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
ELIEVQEGKAKILIPKAESIYDSPVFYNPRMALNRDIVVVLLNILNPKIV
LDALSATGIRGIRFALETPAEEVWLNDISEDAYELMKRNVMLNFDGELRE
SKGRAILKGEKTIVINHDDANRLMAERHRYFHFIDLDPFGSPMEFLDTAL
RSAKRRGILGVTATDGAPLCGAHPRACLRKYLAVPLRGELCHEVGTRILV
GVIARYAAKYDLGIDVILAYYKDHYFRAFVKLKDGARKGDETLEKLGYIY
FDDKTGKFELEQGFLPTRPNAYGPVWLGPLKDEKIVSKMVKEAESLSLAR
KKQALKLLKMIDQELDIPLFYDTHAIGRRKKVEEIISALREQGYEATRTH
FSPTGIKTSAPYEVFIETIKR
3D structure
PDB2ytz Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.216: tRNA (guanine(26)-N(2))-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A R36 L55 A57 I60 R61 D78 I79 D120 A121 D138 F140 F146 R35 L54 A56 I59 R60 D77 I78 D119 A120 D137 F139 F145
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0016423 tRNA (guanine) methyltransferase activity
GO:0016740 transferase activity
GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity
Biological Process
GO:0002940 tRNA N2-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ytz, PDBe:2ytz, PDBj:2ytz
PDBsum2ytz
PubMed18789948
UniProtO59493|TRM1_PYRHO tRNA (guanine(26)-N(2))-dimethyltransferase (Gene Name=trm1)

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