Structure of PDB 2yqu Chain A

Receptor sequence
>2yquA (length=455) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MYDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKA
LLETTERIYEAKKGLLGAKVKGVELDLPALMAHKDKVVQANTQGVEFLFK
KNGIARHQGTARFLSERKVLVEETGEELEARYILIATGSAPLIPPWAQVD
YERVVTSTEALSFPEVPKRLIVVGGGVIGLELGVVWHRLGAEVIVLEYMD
RILPTMDLEVSRAAERVFKKQGLTIRTGVRVTAVVPEAKGARVELEGGEV
LEADRVLVAVGRRPYTEGLSLENAGLSTDERGRIPVDEHLRTRVPHIYAI
GDVVRGPMLAHKASEEGIAAVEHMVRGFGHVDYQAIPSVVYTHPEIAAVG
YTEEELKAQGIPYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGV
HGIGARVGDVLAEAALALFFKASAEDLGRAPHAHPSLSEILKEAALAAWE
RPIHL
3D structure
PDB2yqu Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(E3s) from Thermus thermophilus
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P11 L36 C40 C45 S48 G72 V73 V177 E181 S314 H432 H434 E439
Catalytic site (residue number reindexed from 1) P11 L36 C40 C45 S48 G72 V73 V177 E181 S314 H432 H434 E439
Enzyme Commision number 1.8.1.4: dihydrolipoyl dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G8 G10 P11 G12 E31 K32 G38 T39 C40 R42 G44 C45 K49 T110 A111 T137 G138 S157 I178 Y265 G301 D302 M308 L309 A310 G8 G10 P11 G12 E31 K32 G38 T39 C40 R42 G44 C45 K49 T110 A111 T137 G138 S157 I178 Y265 G301 D302 M308 L309 A310
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding

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Molecular Function
External links
PDB RCSB:2yqu, PDBe:2yqu, PDBj:2yqu
PDBsum2yqu
PubMed
UniProtQ5SLK6

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