Structure of PDB 2ypn Chain A

Receptor sequence
>2ypnA (length=294) Species: 562 (Escherichia coli) [Search protein sequence]
DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVGLFVKELEVA
LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL
PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL
AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL
NHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGS
QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
3D structure
PDB2ypn Accurate and highly complete synchrotron protein crystal Laue diffraction data using the ESRF CCD and the Daresbury Laue software
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K83 D84 R131 R132 R149 R155 C242
Catalytic site (residue number reindexed from 1) K64 D65 R112 R113 R130 R136 C223
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DPM A S81 K83 D84 S128 S129 R131 R132 R155 L169 A170 C242 S62 K64 D65 S109 S110 R112 R113 R136 L150 A151 C223
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ypn, PDBe:2ypn, PDBj:2ypn
PDBsum2ypn
PubMed
UniProtP06983|HEM3_ECOLI Porphobilinogen deaminase (Gene Name=hemC)

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