Structure of PDB 2yol Chain A

Receptor sequence
>2yolA (length=212) Species: 11082 (West Nile virus) [Search protein sequence]
SHMTDMWIERTADITWESDAEITGSSERVDVRLDDDGNFQLMNDPGVLWD
TSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAA
LMSGEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVK
NVQTKPGVFKTPEGEIGAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMP
NGSYISAIVQGE
3D structure
PDB2yol Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus Ns2B-Ns3 Protease.
ChainA
Resolution3.2 Å
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EBN A G83 F85 H1051 D1075 D1129 Y1130 T1132 G1151 N1152 G1153 I1155 Y1161 G37 F39 H94 D118 D172 Y173 T175 G194 N195 G196 I198 Y204 PDBbind-CN: -logKd/Ki=6.89,Ki=0.13uM
BindingDB: Ki=130nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:2yol, PDBe:2yol, PDBj:2yol
PDBsum2yol
PubMed23307694
UniProtP06935|POLG_WNV Genome polyprotein

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