Structure of PDB 2yog Chain A

Receptor sequence
>2yogA (length=197) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
DKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQ
IISKYLKMENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYS
GVAYSSGALNLNKTWCMNPDQGLIKPDVVFYLNVPPNYIYEKVETQKKIY
ETYKHFAHEDYWINIDATRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
3D structure
PDB2yog Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 74X A F44 P45 L59 F74 R78 R99 S103 G104 Y107 F41 P42 L56 F71 R75 R96 S100 G101 Y104 MOAD: Ki=31uM
PDBbind-CN: -logKd/Ki=4.51,Ki=31uM
BindingDB: Ki=31000nM
Gene Ontology
Molecular Function
GO:0004385 guanylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050316 T2-induced deoxynucleotide kinase activity
Biological Process
GO:0006177 GMP biosynthetic process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046710 GDP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yog, PDBe:2yog, PDBj:2yog
PDBsum2yog
PubMed23240776
UniProtQ8I4S1|KTHY_PLAF7 Thymidylate kinase (Gene Name=TMK)

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