Structure of PDB 2yn8 Chain A

Receptor sequence
>2yn8A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
KEIDVSYVKIEEVIGAGEFGEVCRGRLKESCVAIKTLKGGYTERQRREFL
SEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQF
TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFPIR
WTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ
DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMIRNPASLK
IVA
3D structure
PDB2yn8 Stability and Solubility Engineering of the Ephb4 Tyrosine Kinase Catalytic Domain Using a Rationally Designed Synthetic Library.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 P783
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146 P148
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I621 A645 K647 T693 F695 M696 G699 R744 L747 D758 I14 A33 K35 T81 F83 M84 G87 R132 L135 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2yn8, PDBe:2yn8, PDBj:2yn8
PDBsum2yn8
PubMed23840071
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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