Structure of PDB 2ym8 Chain A

Receptor sequence
>2ym8A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
DWDLVQTLGEVQLAVNRVTEEAVAVKIVNIKKEICINKMLNHENVVKFYG
HRREIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI
GITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYV
APELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEK
KTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK
3D structure
PDB2ym8 Structure-Guided Evolution of Potent and Selective Chk1 Inhibitors Through Scaffold Morphing.
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 E134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D106 K108 E110 N111 D124 T146
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YM8 A A36 L84 E85 Y86 C87 E134 L137 S147 D148 A24 L60 E61 Y62 C63 E110 L113 S123 D124 MOAD: ic50=0.013uM
PDBbind-CN: -logKd/Ki=7.89,IC50=13nM
BindingDB: IC50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ym8, PDBe:2ym8, PDBj:2ym8
PDBsum2ym8
PubMed22111927
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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