Structure of PDB 2yls Chain A

Receptor sequence

>2ylsA (length=532) Species: 2021 (Thermobifida fusca) [Search protein sequence]

RQPPEEVDVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGGVWYWNRY
PGARCDIESIEYCYSFSEEVLQEWNWTERYASQPEILRYINFVADKFDLR
SGITFHTTVTAAAFDEATNTWTVDTNHGDRIRARYLIMASGQLSVPQLPN
FPGLKDFAGNLYHTGNWPHEPVDFSGQRVGVIGTGSSGIQVSPQIAKQAA
ELFVFQRTPHFAVPARNAPLDPEFLADLKKRYAEFREESRNTPGGTHRYQ
GPKSALEVSDEELVETLERYWQEGGPDILAAYRDILRDRDANERVAEFIR
NKIRNTVRDPEVAERLVPKGYPFGTKRLILEIDYYEMFNRDNVHLVDTLS
APIETITPRGVRTSEREYELDSLVLATGFDALTGALFKIDIRGVGNVALK
EKWAAGPRTYLGLSTAGFPNLFFIAGPGSPSALSNMLVSIEQHVEWVTDH
IAYMFKNGLTRSEAVLEKEDEWVEHVNEIADETLYPMTASWYTGANVPGK
PRVFMLYVGGFHRYRQICDEVAAKGYEGFVLT

3D structure

PDB

2yls Snapshots of Enzymatic Baeyer-Villiger Catalysis: Oxygen Activation and Intermediate Stabilization.

Chain

Resolution

2.26 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.14.13.92: phenylacetone monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	V22 G23 G25 F26 S27 E46 T47 G53 V54 W55 W57 N58 C65 D66 Y72 T118 V119 S150 G151 Q152 I399 M446 I450	V12 G13 G15 F16 S17 E36 T37 G43 V44 W45 W47 N48 C55 D56 Y62 T108 V109 S140 G141 Q142 I389 M436 I440
BS02	NAP	A	Y60 R64 C65 D66 L153 F161 G193 G195 S196 S197 Q200 R217 T218 H220 K336 R337 A386 T387 G388 W501	Y50 R54 C55 D56 L143 F151 G183 G185 S186 S187 Q190 R207 T208 H210 K326 R327 A376 T377 G378 W491

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0033776	phenylacetone monooxygenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:2yls, PDBe:2yls, PDBj:2yls
PDBsum	2yls
PubMed	21697090
UniProt	Q47PU3\|PAMO_THEFY Phenylacetone monooxygenase (Gene Name=pamO)

[Back to BioLiP]