Structure of PDB 2ylq Chain A

Receptor sequence
>2ylqA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB2ylq Targeting the Binding Function 3 (Bf3) Site of the Human Androgen Receptor Through Virtual Screening.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TES A L701 L704 N705 Q711 M745 M749 F764 T877 M895 L31 L34 N35 Q41 M75 M79 F94 T207 M225 BindingDB: IC50=2.7nM,Ki=3.2nM,EC50=1.1nM
BS02 YLQ A F673 N727 F826 E829 L830 N833 E837 F3 N57 F156 E159 L160 N163 E167 PDBbind-CN: -logKd/Ki=4.30,IC50~50uM
BindingDB: IC50=>10000nM
External links
PDB RCSB:2ylq, PDBe:2ylq, PDBj:2ylq
PDBsum2ylq
PubMed22047606
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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