Structure of PDB 2ylo Chain A

Receptor sequence
>2yloA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPI
ARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB2ylo Targeting the Binding Function 3 (Bf3) Site of the Human Androgen Receptor Through Virtual Screening.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TES A L701 L704 N705 L707 M749 T877 L32 L35 N36 L38 M80 T208 BindingDB: IC50=2.7nM,Ki=3.2nM,EC50=1.1nM
BS02 YLO A P723 G724 R726 N727 F826 E829 L830 N833 Y834 P54 G55 R57 N58 F157 E160 L161 N164 Y165 PDBbind-CN: -logKd/Ki=4.88,IC50=13.1uM
BindingDB: IC50=13100nM
External links
PDB RCSB:2ylo, PDBe:2ylo, PDBj:2ylo
PDBsum2ylo
PubMed22047606
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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