Structure of PDB 2yl8 Chain A

Receptor sequence
>2yl8A (length=434) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
NEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTDLHLLVGNDGLRF
MLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTDLINY
AKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTVDLDN
EQAVAFTKALIDKYAAYFAKKTEIFNIGLDQYANDATDAKGWSVLQADKY
YPNEGYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSF
DKDIIVSMWTGGWGGYDVASSKLLAEKGHQILNTNDAWYYVLGRNADGQG
WYNLDQGLNGIKNTPITSVPKTEGADIPIIGGMVAAWADTPSARYSPSRL
FKLMRHFANANAEYFAADYESAEQALNEVPKDLNRYTAESVTAVKEAEKA
IRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTP
3D structure
PDB2yl8 Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A Q361 N364 W443 Y482 Q181 N184 W263 Y302
BS02 MN A D477 D485 D297 D305
BS03 MN A N422 D447 N242 D267
BS04 MN A E550 E553 E370 E373
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2yl8, PDBe:2yl8, PDBj:2yl8
PDBsum2yl8
PubMed22078560
UniProtP49610|STRH_STRPN Beta-N-acetylhexosaminidase (Gene Name=strH)

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