Structure of PDB 2yjf Chain A

Receptor sequence
>2yjfA (length=352) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVKDSYVGDEAQSKRKYPIEH
GIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIM
FETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPH
AIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDF
ENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAG
IHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPS
TMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRK
CF
3D structure
PDB2yjf Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LAB A L16 P32 Q59 D157 R183 T186 R206 E207 R210 L12 P28 Q41 D134 R160 T163 R183 E184 R187 BindingDB: IC50=8470nM
BS02 ATP A G13 S14 G15 L16 K18 G156 D157 E214 G302 M305 Y306 K336 G9 S10 G11 L12 K14 G133 D134 E191 G279 M282 Y283 K313
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0031013 troponin I binding
GO:0031432 titin binding
GO:0032036 myosin heavy chain binding
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0140660 cytoskeletal motor activator activity
Biological Process
GO:0010628 positive regulation of gene expression
GO:0030041 actin filament polymerization
GO:0030240 skeletal muscle thin filament assembly
GO:0048741 skeletal muscle fiber development
GO:0051017 actin filament bundle assembly
GO:0090131 mesenchyme migration
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031941 filamentous actin
GO:0032432 actin filament bundle
GO:0044297 cell body
GO:0098723 skeletal muscle myofibril

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yjf, PDBe:2yjf, PDBj:2yjf
PDBsum2yjf
PubMed21673315
UniProtP68135|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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