Structure of PDB 2yig Chain A

Receptor sequence
>2yigA (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNF
TRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDD
DETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKFMLP
DDDVQGIQSLYGPGDED
3D structure
PDB2yig Selective Non Zinc Binding Inhibitors of Mmp13.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H222 E223 H226 H232
Catalytic site (residue number reindexed from 1) H119 E120 H123 H129
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5EL A L184 L185 L218 H222 E223 G237 L239 F241 P242 I243 Y244 T245 T247 L81 L82 L115 H119 E120 G134 L136 F138 P139 I140 Y141 T142 T144 MOAD: ic50=79.4nM
PDBbind-CN: -logKd/Ki=7.10,IC50=79.4nM
BindingDB: IC50=125.89nM
BS02 ZN A H222 H226 H232 H119 H123 H129
BS03 CA A D162 N194 G196 D198 D59 N91 G93 D95
BS04 ZN A H172 D174 H187 H200 H69 D71 H84 H97
BS05 CA A D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2yig, PDBe:2yig, PDBj:2yig
PDBsum2yig
PubMed21669521
UniProtP45452|MMP13_HUMAN Collagenase 3 (Gene Name=MMP13)

[Back to BioLiP]