Structure of PDB 2yic Chain A

Receptor sequence
>2yicA (length=814) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
KNARVIELIAAYRNRGHLMADIDPLRLDNTRFRSTLWDLDREFQRKKLRD
ILSVLRDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAEQKYILS
KLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEHGLDEVV
IAMPHRGRLNVLANIVGKPYSQIFSEFEDVKYHLGATGTYIQMFGDNDIE
VSLTANPSHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFSVVPLMLHGDA
AFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDSRSSEYCT
DVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDMLCYRRRG
HNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAEDALRDY
QGQLERVFNEVRELEKHLATAVDKAMLQRIGDAHLALPEGFTVHPRVRPV
LEKRREMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDTQRGTFTQRHA
VIVDRKTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEFAAVGFEYGYS
VGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGH
EGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLRRHGKDGIQRP
LIVFTPKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGEGDRNKVTRLL
LTSGKIYYELAARKAKENREDVAIVRIEQLAPLPRRRLAETLDRYPNVKE
KFWVQEEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAMSAPSSGSSKV
HAVEQQEILDTAFG
3D structure
PDB2yic Functional Plasticity and Allosteric Regulation of Alpha-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism.
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A R540 S604 L606 G644 D645 A646 A647 N678 I680 G681 H747 R156 S208 L210 G248 D249 A250 A251 N282 I284 G285 H351
BS02 MG A D645 N678 I680 D249 N282 I284
BS03 CA A D1004 H1055 D1058 I1060 D591 H642 D645 I647
BS04 TPP A Q901 L950 E952 Q976 F980 Q488 L537 E539 Q563 F567
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:2yic, PDBe:2yic, PDBj:2yic
PDBsum2yic
PubMed21867916
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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