Structure of PDB 2yhw Chain A

Receptor sequence
>2yhwA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
GTLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCV
EAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPL
SDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQH
ELIHGSSFCAAELGHLVVSLNGPDCSCGSHGCIEAYASGMALQREAKKLH
DEDLLLVEGMSVAVGALHLIQAAKLGNAKAQSILRTAGTALGLGVVNILH
TMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLG
AASMVLDYT
3D structure
PDB2yhw Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.60: N-acylmannosamine kinase.
3.2.1.183: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H569 C579 C581 C586 H165 C175 C177 C182
BS02 CA A N516 N519 G548 A565 N112 N115 G144 A161
External links
PDB RCSB:2yhw, PDBe:2yhw, PDBj:2yhw
PDBsum2yhw
PubMed22343627
UniProtQ9Y223|GLCNE_HUMAN Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gene Name=GNE)

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