Structure of PDB 2yhd Chain A

Receptor sequence
>2yhdA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB2yhd Inhibitors of Androgen Receptor Activation Function-2 (Af2) Site Identified Through Virtual Screening.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TES A L701 L704 N705 Q711 F764 T877 M895 L31 L34 N35 Q41 F94 T207 M225 BindingDB: IC50=2.7nM,Ki=3.2nM,EC50=1.1nM
BS02 AV6 A K720 V730 Q733 M734 Q738 M894 I898 K50 V60 Q63 M64 Q68 M224 I228 MOAD: Ki=23uM
PDBbind-CN: -logKd/Ki=4.64,Ki=23.0uM
BindingDB: IC50=18640nM
External links
PDB RCSB:2yhd, PDBe:2yhd, PDBj:2yhd
PDBsum2yhd
PubMed21846139
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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