Structure of PDB 2yfe Chain A

Receptor sequence
>2yfeA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKISKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLN
DQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN
LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETD
MSLHPLLQEIYKDL
3D structure
PDB2yfe Amorfrutins are Potent Antidiabetic Dietary Natural Products
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YFE A R280 I281 C285 R288 L330 I341 S342 M348 R68 I69 C73 R76 L118 I129 S130 M136 MOAD: Ki=0.236uM
PDBbind-CN: -logKd/Ki=6.63,Ki=0.236uM
BindingDB: EC50=458nM,Kd=236nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yfe, PDBe:2yfe, PDBj:2yfe
PDBsum2yfe
PubMed22509006
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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