Structure of PDB 2yel Chain A

Receptor sequence
>2yelA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB2yel Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSH A W81 P82 L92 L94 N140 I146 W40 P41 L51 L53 N99 I105 MOAD: ic50=15.5nM
PDBbind-CN: -logKd/Ki=7.28,Kd=52.5nM
BindingDB: Kd=19nM,IC50=15.5nM
External links
PDB RCSB:2yel, PDBe:2yel, PDBj:2yel
PDBsum2yel
PubMed21568322
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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