Structure of PDB 2yek Chain A

Receptor sequence
>2yekA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
RVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDM
GTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF
LQKVASMPQEEQEL
3D structure
PDB2yek Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EAM A W97 P98 V103 L108 L110 N156 I162 W24 P25 V30 L35 L37 N83 I89 MOAD: ic50=32.5nM
PDBbind-CN: -logKd/Ki=7.21,Kd=61.3nM
BindingDB: IC50=32.5nM,Ki=74nM,Kd=100nM
External links
PDB RCSB:2yek, PDBe:2yek, PDBj:2yek
PDBsum2yek
PubMed21568322
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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