Structure of PDB 2yb0 Chain A

Receptor sequence
>2yb0A (length=258) Species: 5664 (Leishmania major) [Search protein sequence]
ANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSY
PWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKP
LKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDV
IIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDN
SLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWF
ALAKENRL
3D structure
PDB2yb0 The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUR A N25 I28 W41 D79 H82 F83 N183 N19 I22 W35 D73 H76 F77 N177 MOAD: Kd=140uM
PDBbind-CN: -logKd/Ki=3.85,Kd=140uM
BS02 DUR A W60 W61 W54 W55 MOAD: Kd=140uM
PDBbind-CN: -logKd/Ki=3.85,Kd=140uM
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:2yb0, PDBe:2yb0, PDBj:2yb0
PDBsum2yb0
PubMed21454646
UniProtO15826

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