Structure of PDB 2y8w Chain A

Receptor sequence

>2y8wA (length=215) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

GTGAMWLTKLVLNPASRAARRDLANPYEMHRTLSKAVSRALEEGRERLLW
RLEPARGLEPPVVLVQTLTEPDWSVLDEGYAQVFPPKPFHPALKPGQRLR
FRLRANPAKRLAATGKRVALKTPAEKVAWLERRLEEGGFRLLEGERGPWV
QILQDTFLEVRRKKDGEEAGKLLQVQAVLFEGRLEVVDPERALATLRRGV
GPGKALGLGLLSVAP

3D structure

PDB

2y8w An RNA-Induced Conformational Change Required for Crispr RNA Cleavage by the Endoribonuclease Cse3.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R17 Y23 E24 H26 R27 T28 S30 K31 S34 E38 R43 K105 R106 A108 K112 R113 E121 R128 R129 R158 K160 D161 K167 L168 L169 Q170 V171 K200	R21 Y27 E28 H30 R31 T32 S34 K35 S38 E42 R47 K109 R110 A112 K116 R117 E125 R132 R133 R162 K164 D165 K171 L172 L173 Q174 V175 K204	PDBbind-CN: Kd=2.6nM

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity

	Biological Process
GO:0051607	defense response to virus

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Molecular Function

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Biological Process

External links

PDB	RCSB:2y8w, PDBe:2y8w, PDBj:2y8w
PDBsum	2y8w
PubMed	21572442
UniProt	Q53WG9\|CAS6_THET8 CRISPR-associated endoribonuclease Cse3 (Gene Name=cse3)

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