Structure of PDB 2y2i Chain A

Receptor sequence
>2y2iA (length=467) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
ISEITYSDGTVIASIDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEAT
QKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRVE
VGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIA
IDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPA
YWTYRMLRENGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQHTNGY
QTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLR
EVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTGQDENMWLMLSTPRLT
LGGWIGHDDNHSLSQQAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDP
SVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFA
IGGSDADYQNAWSSIVG
3D structure
PDB2y2i Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.129: Transferred entry: 2.4.99.28.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZA3 A A459 S460 K463 S516 N518 M556 G558 T654 A138 S139 K142 S195 N197 M235 G237 T333 PDBbind-CN: -logKd/Ki=4.59,IC50=26uM
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2y2i, PDBe:2y2i, PDBj:2y2i
PDBsum2y2i
PubMed21732689
UniProtQ7CRA4

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