Structure of PDB 2y03 Chain A

Receptor sequence
>2y03A (length=288) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITS
LACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETL
CVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW
RDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR
EAKEQIRSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLV
PDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA
3D structure
PDB2y03 The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A I161 T164 I129 T132
BS02 2CV A P176 W181 N204 Y207 P144 W149 N172 Y175
BS03 2CV A R205 F315 R173 F245
BS04 5FW A D121 S211 F306 F307 N329 D89 S179 F236 F237 N259
BS05 Y01 A I209 A210 I177 A178
BS06 2CV A L152 R157 L120 R125
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2y03, PDBe:2y03, PDBj:2y03
PDBsum2y03
PubMed21228877
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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