Structure of PDB 2xzk Chain A

Receptor sequence
>2xzkA (length=385) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
NDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRI
LAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGT
WGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRR
HLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIP
AMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGY
RMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTS
RRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGA
LVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
3D structure
PDB2xzk The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FKD A R59 I60 D84 Q148 E249 R265 R322 Y358 R38 I39 D63 Q127 E228 R244 R301 Y337
BS02 K99 A S321 R322 R323 D376 F378 T382 S300 R301 R302 D355 F357 T361
BS03 K99 A S330 Y331 D332 K337 F338 N339 S309 Y310 D311 K316 F317 N318
BS04 K99 A P24 A307 P3 A286
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xzk, PDBe:2xzk, PDBj:2xzk
PDBsum2xzk
PubMed21247893
UniProtQ4WQS0|SIA_ASPFU Exo-alpha-sialidase (Gene Name=AFUA_4G13800)

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