Structure of PDB 2xzj Chain A

Receptor sequence
>2xzjA (length=386) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
INDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGR
ILAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAG
TWGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGR
RHLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVI
PAMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKG
YRMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGT
SRRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIG
ALVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
3D structure
PDB2xzj The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights.
ChainA
Resolution1.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KFN A R59 D84 Q148 W202 E249 R265 R322 Y358 R39 D64 Q128 W182 E229 R245 R302 Y338
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2xzj, PDBe:2xzj, PDBj:2xzj
PDBsum2xzj
PubMed21247893
UniProtQ4WQS0|SIA_ASPFU Exo-alpha-sialidase (Gene Name=AFUA_4G13800)

[Back to BioLiP]