Structure of PDB 2xyw Chain A

Receptor sequence
>2xywA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKAFSKHIYNAYLKNFNMTKKKARSILTGKAPFVIHDIETLWQAEKGLV
WKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLND
QVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDI
IEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTI
LRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETET
SLHPLLQEIYKDM
3D structure
PDB2xyw Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy
ChainA
Resolution3.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 08S A W228 V245 C249 T252 T253 F291 L294 V305 I327 I328 H413 W51 V68 C72 T75 T76 F114 L117 V128 I150 I151 H236
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xyw, PDBe:2xyw, PDBj:2xyw
PDBsum2xyw
PubMed21400663
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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