Structure of PDB 2xyr Chain A

Receptor sequence
>2xyrA (length=286) [Search protein sequence]
QAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLCQ
YLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLND
FVSDADSTLIGDCATVHTANKWDLIISDMYDPRTKENDSKEGFFTYLCGF
IKQKLALGGSIAVKITEHSWNADLYKLMGHFSWWTAFVTNVNASSSEAFL
IGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRG
TAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSS
3D structure
PDB2xyr Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A N43 G71 G73 P80 G81 D99 L100 C115 D130 M131 Y132 N41 G69 G71 P78 G79 D97 L98 C113 D128 M129 Y130 PDBbind-CN: -logKd/Ki=6.13,IC50=0.74uM
Gene Ontology
Molecular Function
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2xyr, PDBe:2xyr, PDBj:2xyr
PDBsum2xyr
PubMed21637813
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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