Structure of PDB 2xyj Chain A

Receptor sequence
>2xyjA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLKAFSKHIYNAYLKNFNMTKKKARSILTGSHTAPFVIHDIETLWQAEK
GLVWKQGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLND
QVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDI
IEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTI
LRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETET
SLHPLLQEIYKDM
3D structure
PDB2xyj Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WLM A V245 F246 C249 T252 V305 V312 F324 I327 I328 H413 V68 F69 C72 T75 V128 V135 F147 I150 I151 H236
BS02 WLM A P431 L432 E435 P254 L255 E258
BS03 WLM A L282 K283 V286 L105 K106 V109
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xyj, PDBe:2xyj, PDBj:2xyj
PDBsum2xyj
PubMed21400663
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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