Structure of PDB 2xyi Chain A

Receptor sequence
>2xyiA (length=379) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
SFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ
DGKDYSVHRLILGTHTSDEQNHLLIASVQLPKIEIEIKINHEGEVNRARY
MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG
LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED
VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN
PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI
LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW
NPNEPWIICSVSEDNIMQVWQMAENVYND
3D structure
PDB2xyi Chromatin-Modifying Complex Component Nurf55/P55 Associates with Histones H3, H4 and Polycomb Repressive Complex 2 Subunit Su(Z)12 Through Partially Overlapping Binding Sites.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I27 W28 N31 L35 D362 D365 G366 L370 I373 I17 W18 N21 L25 D326 D329 G330 L334 I337
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006335 DNA replication-dependent chromatin assembly
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007307 eggshell chorion gene amplification
GO:0007346 regulation of mitotic cell cycle
GO:0007379 segment specification
GO:0031507 heterochromatin formation
GO:0034728 nucleosome organization
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0140718 facultative heterochromatin formation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005700 polytene chromosome
GO:0016581 NuRD complex
GO:0016589 NURF complex
GO:0031523 Myb complex
GO:0033186 CAF-1 complex
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
GO:0070822 Sin3-type complex
GO:0090575 RNA polymerase II transcription regulator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xyi, PDBe:2xyi, PDBj:2xyi
PDBsum2xyi
PubMed21550984
UniProtQ24572|CAF1_DROME Chromatin assembly factor 1 p55 subunit (Gene Name=Caf1-55)

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