Structure of PDB 2xya Chain A

Receptor sequence
>2xyaA (length=182) Species: 169066 (Human rhinovirus sp.) [Search protein sequence]
GSGPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTHADPGKEIQ
VDGITTKVIDSYDLYNKNGIKLEITVLKLDRNEKFRDIRRYIPNNEDDYP
NCNLALLANQPEPTIINVGDVVSYGNILLSGNQTARMLKYSYPTKSGYCG
GVLYKIGQVLGIHVGGNGRDGFSAMLLRSYFT
3D structure
PDB2xya Non-Covalent Inhibitors of Rhinovirus 3C Protease.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H42 E73 G147 C149
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7L4 A T142 K143 S144 C147 H161 G163 G164 N165 G166 T144 K145 S146 C149 H163 G165 G166 N167 G168 MOAD: Kd=200uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2xya, PDBe:2xya, PDBj:2xya
PDBsum2xya
PubMed21183345
UniProtP04936|POLG_HRV2 Genome polyprotein

[Back to BioLiP]