Structure of PDB 2xxz Chain A

Receptor sequence
>2xxzA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
REKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLG
LFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTI
AKYAQYQASSFQESLQEEHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFM
RVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIG
PGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRF
VQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLA
3D structure
PDB2xxz Crystal Structure of the Human Jmjd3 Jumonji Domain
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8XQ A Y1376 K1378 T1384 H1387 E1389 N1397 W1407 H1467 N1477 Y175 K177 T183 H186 E188 N196 W206 H266 N276 BindingDB: IC50=100nM
External links
PDB RCSB:2xxz, PDBe:2xxz, PDBj:2xxz
PDBsum2xxz
PubMed
UniProtO15054|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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