Structure of PDB 2xxv Chain A

Receptor sequence
>2xxvA (length=248) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIR
LVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIST
YDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCN
LTQIGGLIDSKGYGVGTPKGSPYRDKITIAILQLQEEGKLHMMKEKWW
3D structure
PDB2xxv Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 KAI A E440 Y488 P516 A518 R523 G688 A689 T690 E738 E9 Y57 P85 A87 R92 G137 A138 T139 E187 BindingDB: Ki=12.7nM,Kd=39nM,EC50=1800nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function

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Cellular Component
External links
PDB RCSB:2xxv, PDBe:2xxv, PDBj:2xxv
PDBsum2xxv
PubMed21414913
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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