Structure of PDB 2xxr Chain A

Receptor sequence
>2xxrA (length=248) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIR
LVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIST
YDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCN
LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW
3D structure
PDB2xxr Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y488 A518 R523 G688 A689 T690 E738 Y57 A87 R92 G137 A138 T139 E187 PDBbind-CN: -logKd/Ki=6.55,Ki=280nM
BS02 NA A E524 I527 D528 M770 E93 I96 D97 M219
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2xxr, PDBe:2xxr, PDBj:2xxr
PDBsum2xxr
PubMed21414913
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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