Structure of PDB 2xwm Chain A

Receptor sequence
>2xwmA (length=220) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
ATVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRASGVIDRIVI
AVPPALTDESKLVFGGEDSVIVSGGVDRTESVALALEAAGDAEFVLVHDA
ARALTPPALIARVVAALKEGHSAVVPGLAPADTIKAVDANGAVLGTPERA
GLRAVQTPQGFHADVLRRAYARATAGGVTDDASLVEQLGTPVQIVDGDPL
AFKITTPLDLVLAEAVLAHH
3D structure
PDB2xwm Structural and Functional Studies on Mycobacterial Ispd Enzymes
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.60: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A P8 A9 A10 G11 K22 V77 D78 R79 S82 D100 K204 P7 A8 A9 G10 K21 V76 D77 R78 S81 D99 K203
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0016779 nucleotidyltransferase activity
GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:2xwm, PDBe:2xwm, PDBj:2xwm
PDBsum2xwm
PubMed21543842
UniProtA0R560

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