Structure of PDB 2xvd Chain A

Receptor sequence
>2xvdA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLYTERQRR
EFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLND
GQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDF
GLSRFLESSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGE
RPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFP
QVVSALDKMIRNPASLKIVA
3D structure
PDB2xvd Inhibitors of the Tyrosine Kinase Ephb4. Part 4: Discovery and Optimization of a Benzylic Alcohol Series.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 K781 P783
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 K163 P165
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AS6 A I621 V629 A645 K647 E664 T693 M696 E697 G699 L747 S757 D758 I15 V23 A39 K41 E55 T84 M87 E88 G90 L138 S148 D149 MOAD: ic50=0.002uM
PDBbind-CN: -logKd/Ki=8.70,IC50=0.002uM
BindingDB: IC50=7nM
BS02 MG A D740 D758 D131 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xvd, PDBe:2xvd, PDBj:2xvd
PDBsum2xvd
PubMed21441027
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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