Structure of PDB 2xue Chain A

Receptor sequence
>2xueA (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]
REKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLG
LFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTI
AKYAQYQASSFQESLHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTS
TGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDC
EWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRP
GDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNV
KSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAG
KKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENNTYLVHCEGCARRRSA
GLQGVVVLEQYRTEELAQAYDAFTLAP
3D structure
PDB2xue A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1575 C1578 C1602 C1605 C367 C370 C391 C394
BS02 FE A H1390 E1392 H1470 H182 E184 H262
BS03 AKG A K1381 T1387 H1390 E1392 S1398 N1400 H1470 K173 T179 H182 E184 S190 N192 H262
External links
PDB RCSB:2xue, PDBe:2xue, PDBj:2xue
PDBsum2xue
PubMed22842901
UniProtO15054|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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