Structure of PDB 2xuc Chain A

Receptor sequence
>2xucA (length=310) [Search protein sequence]
FSNLAIYWGQGPNQLRLSHFCQETSLDIINIGFINYFPDMSPGHWPGSNF
GNQCDGSVYVTNDGVVTKLLSGCHQIMEDIPICQAAGKKVLLSIGGAYPP
DQSILSEDSAVAFATFLWGAFGPVAEGWEGPRPFGDVVVDGFDFDIEHNG
GFGYATMVNTFRQYFNQVPERKFYLSAAPQCIIPDAQLSDAIFNAAFDFI
WIQYYNTAACSAKSFIDTSLGTFNFDAWVTVLKASASKDAKLYVGLPASE
TAANQGYYLTPDEVESLVSTYMDRYPDTFGGIMLWEATASENNQIDGAPY
ADHMKDILLH
3D structure
PDB2xuc Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XRG A Y34 D172 E174 Q230 Y232 W312 Y7 D145 E147 Q203 Y205 W285 MOAD: ic50=79uM
PDBbind-CN: -logKd/Ki=4.10,IC50=79uM
BS02 XRG A Q37 N76 A124 W312 Q10 N49 A97 W285 MOAD: ic50=79uM
PDBbind-CN: -logKd/Ki=4.10,IC50=79uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2xuc, PDBe:2xuc, PDBj:2xuc
PDBsum2xuc
PubMed21168763
UniProtQ873Y0|CHIA1_ASPFM Endochitinase A1 (Gene Name=chiA1)

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