Structure of PDB 2xtk Chain A

Receptor sequence
>2xtkA (length=310) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
FSNLAIYWGQGPNQLRLSHFCQETSLDIINIGFINYFPDMSPGHWPGSNF
GNQCDGSVYVTNDGVVTKLLSGCHQIMEDIPICQAAGKKVLLSIGGAYPP
DQSILSEDSAVAFATFLWGAFGPVAEGWEGPRPFGDVVVDGFDFDIEHNG
GFGYATMVNTFRQYFNQVPERKFYLSAAPQCIIPDAQLSDAIFNAAFDFI
WIQYYNTAACSAKSFIDTSLGTFNFDAWVTVLKASASKDAKLYVGLPASE
TAANQGYYLTPDEVESLVSTYMDRYPDTFGGIMLWEATASENNQIDGAPY
ADHMKDILLH
3D structure
PDB2xtk Acetazolamide-Based Fungal Chitinase Inhibitors.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZM A Y34 D172 E174 Q230 Y232 N233 W312 Y7 D145 E147 Q203 Y205 N206 W285 MOAD: ic50=164uM
PDBbind-CN: -logKd/Ki=3.79,IC50=164uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2xtk, PDBe:2xtk, PDBj:2xtk
PDBsum2xtk
PubMed21044846
UniProtB0Y2Y2

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