Structure of PDB 2xsb Chain A

Receptor sequence
>2xsbA (length=424) Species: 314256 (Oceanicola granulosus HTCC2516) [Search protein sequence]
MLTGVIEGFYGRDWRRDERATVMDWIAAAGMNTYIYGPKDDVHVRARWRV
PYDAAGLARLTELRDAAAARGMVFYVSLAPCLDVTYSDPQDRAALLARVD
QLARAGLRNLVLLFDDIPSVLPEADRFDSFAEAQADLSNMVLRHLRGAGH
VVFCPTEYCGRMAGGDPRGSAYLQRLGSTLDPAIDIFWTGPEIVSEEIVA
AHLAAVGEVLRRRPVIWDNFHANDYDIRRVFAGPLGGRSRDILPLVAGWI
TNPNNEAEANFPAIHTTGAYLADPDYAPERAIAAAVAAWQPRFRLAFGDG
AVPSDLVALLCDLFWQPFALGPETTRILSALRAALTVPRPDPSDPAWRAA
LEDLRDLKRRINKLFTLMTEIENRDLFHTFHNYLWEAQEEVGHLVAYCDW
LDEAPPPGAVFPARGFGVAVQDIL
3D structure
PDB2xsb Human Oga Binds Substrates in a Conserved Peptide Recognition Groove.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDL A G8 Y160 I195 W219 N221 D226 N254 G8 Y158 I193 W217 N219 D224 N252 MOAD: ic50=11uM
PDBbind-CN: -logKd/Ki=4.96,IC50=11uM
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2xsb, PDBe:2xsb, PDBj:2xsb
PDBsum2xsb
PubMed20863279
UniProtQ2CEE3|OGA_OCEGH Protein O-GlcNAcase (Gene Name=OG2516_04129)

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