Structure of PDB 2xs0 Chain A

Receptor sequence
>2xs0A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIK
KLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVY
IVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS
NIVVKSDCTLKILDFGLATRYYRAPEVILGMGYKENVDIWSVGCIMGEMI
KGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGY
SFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHP
YINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEE
3D structure
PDB2xs0 Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D146 K148 N151 D164 T169
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q117 M121 E126 R127 S161 D162 V323 W324 D326 E329 Q112 M116 E121 R122 S156 D157 V304 W305 D307 E310
BS02 ANP A I32 Q37 V40 A53 M108 M111 N114 S155 L168 I27 Q32 V35 A48 M103 M106 N109 S150 L163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2xs0, PDBe:2xs0, PDBj:2xs0
PDBsum2xs0
PubMed23047924
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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