Structure of PDB 2xrw Chain A

Receptor sequence
>2xrwA (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
GSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILER
NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE
FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHR
DLKPSNIVVKSDCTLKILDFGLRYYRAPEVILGMGYKENVDIWSVGCIMG
EMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKY
AGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL
QHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEH
3D structure
PDB2xrw Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
ChainA
Resolution1.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D151 K153 N156 D169
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q117 M121 E126 R127 Y130 K160 S161 D162 C163 Q117 M121 E126 R127 Y130 K160 S161 D162 C163
BS02 ANP A I32 S34 V40 A53 K55 M111 N114 S155 N156 L168 I32 S34 V40 A53 K55 M111 N114 S155 N156 L168
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xrw, PDBe:2xrw, PDBj:2xrw
PDBsum2xrw
PubMed23047924
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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