Structure of PDB 2xq0 Chain A

Receptor sequence
>2xq0A (length=625) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSV
TFQLKKLHNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVI
NNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAIHARS
LFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTNIYRFEQKVPIPAYLI
GIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEY
EWGTYDILVNVDSYPYGGMESPNMTFATPTLLAHDRSNIDVIAHELAHSW
SGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQN
SIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGK
AEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYK
PGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFN
SNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNA
EVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLA
LATFDKFKDTYHPICKALVKQDLKL
3D structure
PDB2xq0 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
ChainA
Resolution1.955 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E316 H340 E341 H344 E363 D421 Y429
Catalytic site (residue number reindexed from 1) E270 H294 E295 H298 E317 D375 Y383
Enzyme Commision number 3.3.2.10: soluble epoxide hydrolase.
3.4.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BES A E186 Y312 G313 G314 E316 H340 H344 E363 Y429 E144 Y266 G267 G268 E270 H294 H298 E317 Y383
BS02 ZN A H340 H344 E363 H294 H298 E317
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
GO:0043171 peptide catabolic process
GO:0044255 cellular lipid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:2xq0, PDBe:2xq0, PDBj:2xq0
PDBsum2xq0
PubMed21146536
UniProtQ10740|LKHA4_YEAST Leucine aminopeptidase 2 (Gene Name=LAP2)

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