Structure of PDB 2xpy Chain A

Receptor sequence
>2xpyA (length=628) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSV
TFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSR
LVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAIH
ARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTNIYRFEQKVPIPA
YLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKII
FEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELA
HSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSD
LQNSIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETIL
GGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETW
LYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIK
DFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKS
QNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDR
RLALATFDKFKDTYHPICKALVKQDLGL
3D structure
PDB2xpy A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
ChainA
Resolution2.73 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E316 H340 E341 H344 E363 D421 Y429
Catalytic site (residue number reindexed from 1) E273 H297 E298 H301 E320 D378 Y386
Enzyme Commision number 3.3.2.10: soluble epoxide hydrolase.
3.4.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H340 H344 E363 H297 H301 E320
BS02 GSH A H97 C147 D149 H58 C108 D110
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
GO:0043171 peptide catabolic process
GO:0044255 cellular lipid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xpy, PDBe:2xpy, PDBj:2xpy
PDBsum2xpy
PubMed21146536
UniProtQ10740|LKHA4_YEAST Leucine aminopeptidase 2 (Gene Name=LAP2)

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