Structure of PDB 2xpg Chain A

Receptor sequence

>2xpgA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYG
CDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAA
HEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRW

3D structure

PDB

2xpg Structure of Hla-A0301 in Complex with a Peptide of Proteolipid Protein: Insights Into the Role of Hla-A Alleles in Susceptibility to Multiple Sclerosis

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y7 Q62 E63 N66 V67 A69 Q70 D77 Y99 D116 T143 K146 W147 E152 Q155 Y159 W167 Y171	Y7 Q62 E63 N66 V67 A69 Q70 D77 Y99 D116 T143 K146 W147 E152 Q155 Y159 W167 Y171

External links

PDB	RCSB:2xpg, PDBe:2xpg, PDBj:2xpg
PDBsum	2xpg
PubMed	21543847
UniProt	P04439\|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)

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