Structure of PDB 2xlr Chain A

Receptor sequence

>2xlrA (length=446) Species: 230105 (Methylophaga aminisulfidivorans) [Search protein sequence]

MATRIAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYT
WRTGLDENGEPVHSSMYRYLWSDGPKECLEFADYTFDEHFGKPIASYPPR
EVLWDYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTI
YSAAFDYVVCCTGHFSTPYVPEFEGFEKFGGRILHAHDFRDALEFKDKTV
LLVGSSYSAEDIGSQCYKYGAKKLISCYRTAPMGYKWPENWDERPNLVRV
DTENAYFADGSSEKVDAIILCTGYIHHFPFLNDDLRLVTNNRLWPLNLYK
GVVWEDNPKFFYIGMQDQWYSFNMFDAQAWYARDVIMGRLPLPSKEEMKA
DSMAWREKELTLVTAEEMYTYQGDYIQNLIDMTDYPSFDIPATNKTFLEW
KHHKKENIMTFRDHSYRSLMTGTMAPKHHTPWIDALDDSLEAYLSD

3D structure

PDB

2xlr Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase.

Chain

Resolution

2.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G14 G16 P17 S18 E43 K44 G50 Q51 W52 H68 M71 D78 V131 T167 F170 Q323 S326 F330	G9 G11 P12 S13 E38 K39 G45 Q46 W47 H63 M66 D73 V126 T162 F165 Q318 S321 F325
BS02	NAP	A	D78 G209 S210 S211 Y212 S213 R234 T235 N251 C276 T277 D322 Q323	D73 G204 S205 S206 Y207 S208 R229 T230 N246 C271 T272 D317 Q318

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:2xlr, PDBe:2xlr, PDBj:2xlr
PDBsum	2xlr
PubMed	20807767
UniProt	Q83XK4

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