Structure of PDB 2xkc Chain A

Receptor sequence
>2xkcA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS
EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKE
RQYLDEEFVLRVMTQLTLALKECHRRSLKPANVFLDGKQNVKLGDGTPYY
MSPEQMNRNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRR
IPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB2xkc Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) K129 A131 N132 D145 T147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4VQ A I14 C22 V35 K37 M86 C89 G92 F148 G158 I12 C18 V31 K33 M82 C85 G88 F134 G144 MOAD: ic50=2.6uM
PDBbind-CN: -logKd/Ki=5.59,IC50=2.6uM
BindingDB: IC50=2300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xkc, PDBe:2xkc, PDBj:2xkc
PDBsum2xkc
PubMed20936789
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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